New Directions in Chemistry to Impact Novel Therapeutics

Date & time

11am–12pm 10 October 2013


RSC, Building 138, Room 3.105


Professor Andrew Phillips, Yale University, Connecticut, USA


 Professor Michael Sherburn

Systematic characterizations of disease biology are providing remarkable insights into the genetic basis and subsequent dependencies of many cancers and an unprecedented stream of potential targets for intervention.  These targets include many historically “undruggable” classes including transcription factors, protein-protein interactions, protein-oligonucleotide interactions, and lncRNAs. 
This seminar will describe the challenges of discovering small molecules that affect transcription factors, protein-protein interactions, and lncRNAs.   Opportunities for chemistry that span computation, synthesis, and mass spectrometry will be illustrated by examples from  programs directed at the discovery of small molecules targeting HDM2/HDMX, BCL6, and the lncRNA HOTAIR.


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