Studies towards the synthesis of tetra-deoxy nonulsonic acids

Date & time

2–3pm 17 September 2014


Building 138, Seminar Room


Dr Milton Kiefel


 Gavin Perri

Carbohydrates play an important role in a range of human diseases.  The nonulosonic acids are a family of 9-carbon sugars that include the sialic acids (e.g. N-acetylneuraminic acid).  It is well known that sugars like sialic acid are intimately involved in a number of diseases, including viral and bacterial infections in humans.  More recently some tetradeoxy-nonulosonic acids like legionaminic acid (Leg, 1) and pseudaminic acid (Pse, 2) have been found as components of bacterial glycans.  Whilst the precise biological roles of these sugars is not exactly clear, there is considerable interest in the possibility that they aid bacterial virulence and infectivity.  
This presentation will describe our recent efforts in developing novel and viable synthetic protocols to enable the efficient synthesis of analogues of legionaminic and pseudaminic acid.

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