Skip navigation
The Australian National University

Professor Margaret Harding

Deputy Vice-Chancellor (Research)
Bsc Phd DSc (Sydney)
pause icon 61 2 61258487

Biography

Ph.D. 1987 University of Sydney; D.Sc. 2002 University of Sydney; Postdoctoral Fellow, Université Louis Pasteur, Strasbourg, France 1986-1988; Ramsay Memorial Fellow, Cambridge University, UK, 1989-1989; Lecturer (1990), Senior Lecturer (1994) Associate Professor (1999) Professor (2005) University of Sydney; DNA Programme Leader, CRC for Molecular Engineering, 1992-1998; RACI Rennie Medal, 1993; RACI Biota Medal for Medicinal Chemistry, 1995; RACI Nyholm Youth Lecturer, 1999; Vice-Chancellor's Award for Excellence in Postgraduate Supervision, 2002; Deputy Head, School of Chemistry, 2000-2005; Associate Dean for Postgraduate Research, Faculty of Science, University of Sydney, 2000-2004; Member of ARC College of Experts, 2004-2006. Dean of Graduate Research & Professor of Chemistry, UNSW, 2005-2008; Pro Vice-Chancellor (Research Strategy) & Dean of Graduate Research, UNSW April 2008 - 2009; Pro Vice-Chancellor (Research) 2010-2012; Deputy Vice-Chancellor (Research) at ANU since June 2012; Visiting Professorial Fellow UNSW 2012-2015.

Research

Research interests

Research in the Medicinal and Biomolecular Chemistry group centres on understanding, at the molecular level, the highly specific intermolecular interactions that occur in almost all biological systems. Major current programmes involve the study of the interactions of small molecules with DNA, and the properties and the mechanism of ice growth inhibition by fish antifreeze proteins.
 

Publications

RESEARCH PUBLICATIONS & PATENTS

 

1. M.M. Catalano, M.J. Crossley, M.M. Harding and L.G. King,

Control of Reactivity at the Porphyrin Periphery by Metal Ion Coordination : A General Method for Specific Nitration at the b-Pyrrolic Position of 5,10,15,20-Tetra-arylporphyrins,

J. Chem. Soc., Chem. Commun., 1984, 1535-1536.

 

2. M.J. Crossley, M.M. Harding and S. Sternhell,

Tautomerism in 2-Substituted 5,10,15,20-Tetraphenylporphyrins,

J. Am. Chem. Soc., 1986, 108, 3608-3613.

 

3. M.J. Crossley, L.D. Field, A.J. Forster, M.M. Harding and S. Sternhell,

Steric Effects on Atropisomerism in Tetra-arylporphyrins,

 J. Am. Chem. Soc., 1987, 109, 341-348.

 

4. M.J. Crossley, L.D. Field, M.M. Harding and S. Sternhell,

Kinetics of Tautomerism in 2-Substituted 5,10,15,20-Tetraphenylporphyrins: Directionality of Proton Transfer Between Inner Nitrogens,

J. Am. Chem. Soc., 1987, 109, 2335-2341.

 

5. M.J. Crossley, M.M. Harding and S. Sternhell,

Tautomerism in 2-Hydroxy-5,10,15,20-tetraphenylporphyrin: An Equilibrium Between Enol, Keto, and Aromatic Hydroxyl Tautomers,

J. Org. Chem., 1988, 53, 1132-1137.

 

6. J.-M. Lehn, A. Rigault, J. Siegel, M. Harding and Y.-B. He,

Oligobipyridine Ligands : Process for Obtaining them and Application as Complexation Agents,

PCT Int. Appl. WO 8808419, 1988.

 

7. U. Koert, M.M. Harding and J.-M. Lehn,

DNH-Deoxyribonucleohelicates: Self-Assembly of Oligonucleosidic Double-Helical Metal Complexes,

Nature, 1990, 346, 339-342.

 

8. U. Koert, M.M. Harding and J.-M. Lehn,

DNH-Deoxyribonucleohelicates: Self-Assembly of Oligonucleosidic Double-Helical Metal Complexes,

Chemtracts: Org. Chem., 1990, 446-447.

 

9. M.M. Harding, D.H. Williams and D.N. Woolfson,

Characterization of a Partially Denatured State of a Protein by 2D NMR: Reduction of the Hydrophobic Interactions in Ubiquitin,

Biochemistry, 1991, 30, 3120-3128.

 

10. D.N. Woolfson, M.M. Harding, P.A. Evans and D.H. Williams,

Structure in a Partially Folded State of Ubiquitin as Determined by NMR,

Tech. Pretein Chem. 2, Ed., J.J. Villafranca, Academic Press, 1991, 283-293.

 

11. M.M. Harding, U. Koert, J.-M. Lehn, A. Marquis-Rigault, C. Piguet and J. Siegel,

Synthesis of Unsubstituted and 4,4'-Substituted Oligobipyridines as Ligand Strands for Helicate Self-Assembly,

Helv. Chim. Acta, 1991, 74, 594-610.

 

12. N.J. Skelton, M.M. Harding, R.J. Mortishire-Smith, S.K. Rahman, D.H. Williams, M.J. Rance and J.C. Ruddock,

Structure  Elucidation and Solution Conformation of the Glycopeptide Antibiotic Ramoplanose (UK-71,903): A Cyclic Depsipeptide Containing an Antiparallel b-Sheet and a b-Bulge,

J. Am. Chem. Soc., 1991, 113, 7522-7530.

 

13. M.J. Crossley, M.M. Harding and S. Sternhell,

Direct Observation of Tautomeric Forms of Deuteroporphyrin Derivatives by 1H NMR Spectroscopy : Substituent Effects and Structure Implications,

J. Org. Chem., 1992, 57, 1833-1837.

 

14. M.J. Crossley, M.M. Harding and S. Sternhell,

Use of NMR Spectroscopy to Determine Bond Orders Between b - and b '-Pyrrolic Positions of Porphyrins: Structural Differences Between Free-Base Porphyrins and Metalloporphyrins,

J. Am. Chem. Soc., 1992, 114, 3266-3272.

 

15. M.M.Harding,

NMR Studies on YSPTSPSY: Implications for the Design of DNA Bisintercalators,

J. Med. Chem., 1992, 35, 4658-4664.

 

16. R. Deschenaux, M.M. Harding, T. Ruch and R. Ziessel,

Synthesis, Characterization and Properties of Organometallic Cyclodextrins, Minutes Int. Symp. Cyclodextrins,

Proceedings of the Sixth International Symposium on Cyclodextrins, Ed. Hedges, A. R.; Ed. Sante: Paris, France, 1992, 101-105.

 

17. D.N. Woolfson, A. Cooper, M.M. Harding, D.H. Williams and P.A. Evans,

Protein Folding in the Absence of the Solvent Ordering Contribution to the Hydrophobic Interaction,

J. Mol. Biol., 1993, 229, 502-511.

 

18. M.M. Harding, G.J. Harden and L.D. Field,

A 31P NMR Study of the Interaction of the Antitumour Active Metallocene Cp2MoCl2 with Calf Thymus DNA,

FEBS Lett., 1993, 3, 291-294.

 

19. R. Deschenaux, M.M. Harding and T. Ruch,

Synthesis and a High Field NMR Study of a 2,2'-Bipyridyl Substituted b-Cyclodextrin and its Luminescent Re(I) Metal Complex,

J. Chem. Soc., Perkin Trans. 2, 1993, 1251-1258.

 

20. S.E. Boyd, M.M. Harding, I.E. Buys and T.W. Hambley,

Synthesis and Structure of Diacetato-[1-Benzyloxy-1,1-bis(N-methylimidazol-2-yl)ethane]zinc(II),

Aust. J. Chem., 1993, 46, 1307-1312.

 

21. M.M. Harding, G.V. Long and C.L. Brown,

Solution Conformation of the Antitumor Drug Streptonigrin,

J. Med. Chem., 1993, 36, 3056-3060.

 

22. G.V. Long, S.E. Boyd, M.M. Harding, I.E. Buys and T.W. Hambley,

Synthesis, Properties and Complexation Studies on 3-Amino-6,6'-dimethyl-2,2'-bipyridine,

J. Chem. Soc., Dalton Trans., 1993, 3175-3180.

 

23. A. Bilyk and M.M. Harding,

Assembly of [2 + 2] Bimetallic Macrocyclic Complexes from Bis(bipyridyl) Ligands and Metal Ions,

J. Chem. Soc., Dalton Trans., 1994, 77-82.

 

24. C.L. Brown and M.M. Harding,

Synthetic a-Helical Peptides Incorporating Intercalators for DNA Recognition,

J. Mol. Recognit., 1994, 7, 215-220.

 

25. M.M. Harding, B. Sargeant, A. Bilyk and S. Augoloupis,

Binuclear Complexes from Tetraimidazole Ligands and Zn(II) Ions,

Aust. J. Chem., 1994, 47, 1133-1142.

 

26. J.H. Murray and M.M. Harding,

Organometallic Anticancer Agents : The Effect of the Central Metal and Halide Ligands on the Interaction of Metallocene Dihalides Cp2MX2 with Nucleic Acid Constituents,

J. Med. Chem., 1994, 37, 1936-1941.

 

27. C.L. Brown, M.M. Harding, J.R. Kalman, C.E. Marjo, S. Rainone and L.K. Webster,

Synthesis and Biological Activity of Intercalator Substituted Bile Steroids,

Bioorg. & Med. Chem. Lett., 1994, 4, 1253-1256.

 

28. M.J. Crossley, M.M. Harding and C.W. Tansey,

A Convenient Synthesis of 2-Alkyl-5,10,15,20-tetraphenylporphyrins: Reaction of Metallo-2-Nitro-5,10,15,20-tetraphenylporphyrins with Grignard and Organolithium Reagents,

J. Org. Chem., 1994, 59, 4433-4437.

 

29. A. Bilyk, M.M. Harding, P. Turner and T.W. Hambley,

Factors Affecting the Assembly of Helical and Non-helical Zinc(II) Bipyridyl Metallomacrocycles,

J. Chem. Soc., Dalton Trans., 1994, 2783-2790.

 

30. G.Y. Krippner and M.M. Harding,

Intercalator Amino Acids. Synthesis of Heteroaryl Alanines,

Tetrahedron: Asymmetry, 1994, 5, 1793-1804.

 

31. M.M. Harding and C.L. Brown,

Australian Membrane and Biotechnology Research Institute and the University of Sydney, DNA Sensor,

Australian Provisional Patent Application No. PM7717, 26 August 1994.

 

32. G.V. Long, M.M. Harding, M.C.L. Xie, I.E. Buys and T.W. Hambley,

3-Amino-6,6'-dimethoxycarbonyl-2,2'-bipyridine dimethylester, a Model for the Central Chelation Unit of Streptonigrin.

J. Chem. Soc., Dalton Trans., 1995, 951-955.

 

33. C. J. Shelton and M. M. Harding,

Synthesis and DNA Binding of the Methyl a-L-Glycosides of Anthracycline Carbohydrate Sidechains,

J. Chem. Research, 1995, 158 (M, 1201-1219).

 

34. A. Bilyk, M.M. Harding, P. Turner and T. W. Hambley,

Octahedral Non-helical Bis(pypyridyl) Metallomacrocyles,

J. Chem. Soc., Dalton Trans., 1995, 2549-2553.

 

35. A. Bilyk and M.M. Harding,

Guest-Induced Assembly of a Chiral [2+2] Metallomacrocyle,

J. Chem. Soc., Chem. Commun., 1995, 1697-1698.

 

36. G.V. Long, M.M. Harding, P. Turner and T.W. Hambley,

Copper(II) Bipyridyl and Iminopyridyl Analogues of Streptonigrin,

J. Chem. Soc., Dalton Trans., 1995, 3905-3910.

 

37. G.V. Long and M.M. Harding,

A 1H NMR Study of the Interaction of Zinc(II) with the Antitumor Drug Streptonigrin,

J. Chem. Soc., Dalton Trans., 1996, 549-552.

 

38. C.L. Brown, M.M. Harding, G.Y. Krippner, S. Rainone and L.K. Webster,

Preparation and Biological Activity of Heteroaryl-Substituted Bile Steroids,

Aust. J. Chem., 1996, 49, 7-11.

 

39. C.J. Shelton, M.M. Harding, and A.S. Prakash,

Enzymatic and Chemical Footprinting of Anthracycline Antitumor Antibiotics and Related Saccharide Side Chains,

Biochemistry, 1996, 35, 7974-7982.

 

40. J.P. Mackay, C.J. Shelton and M.M. Harding,

Assignment of 1H NMR Spectrum and Solution Conformation of the Antitumour Antibiotic

Ditrisarubicin B,

Tetrahedron, 1996, 52, 5617-5624.

 

41. M.M. Harding and S. Wright Lucas,

US Provisional Patent Application Serial No. 60/018,125 Nucleic Acid Sensor,

Aust Membrane and Biotech. Research Institute and University of Sydney, 23 May 1996.

 

42. M.M. Harding and J.-M. Lehn

Synthesis of Oligobipyridine Strands Bearing Nucleoside and Amino Acid Side Chains,

Aust. J. Chem., 1996, 49, 1023-1027.

 

43. M.M. Harding,

Medicinal Chemistry : DNA as a Target,

Chem. in Aust., 1996, 220-222.

 

44. M.M. Harding, M. Prodigalidad and M.J. Lynch,

Organometallic Anticancer Agents. 2 . Aqueous Chemistry and Interaction of Niobocene Dichloride with Nucleic Acid Constituents and Amino Acids,

J. Med. Chem., 1996, 39, 5012-5016.

45. M.M. Harding, G.Y. Krippner, C.J. Shelton, A. Rodger, K.J. Sanders, J.P. Mackay and A.S. Prakash,

DNA-Binding Studies of XSPTSPSZ, Derivatives of the Intercalating Heptad Repeat of RNA Polymerase II,

Biopolymers, 1997, 42, 387-398.

46. G.V. Long, M.M. Harding, J.-Y. Fan and W.A. Denny,

Interaction of the Antitumor Antibiotic Streptonigrin with DNA and Oligonucleotides,

Anti-Cancer Drug Design, 1997, 12, 453-472.

 

47. M.M. Harding , S. Wright Lucas, P. Arensdorf and V. Braach-Makyvitis,

Full PCT Patent Application 60/018,125, Nucleic Acid Sensor,

Aust Membrane and Biotech. Research Institute and University of Sydney, 23 May 1997.

 

48. M.A. Houghton, A. Bilyk, M.M. Harding, P. Turner and T.W. Hambley,

Effect of Guest Molecules, Metal Ions and Linker Length on the Assembly of Chiral [2+2] Metallomacrocyles: Solution Studies and Crystal Structures,

J. Chem. Soc., Dalton Trans., 1997, 2725-2733.

 

49. M.M. Harding and G.V. Long,

Interaction of the Antitumor Antibiotic Streptonigrin with Metal Ions and DNA,

Current Medicinal Chemistry, 1997, 4, 405-420.

 

50.  R.W. Baker, A.V. George and M. M. Harding,

Models and Molecules - A Workshop on Stereoisomers,

J. Chem. Ed., 1998, 75, 853-855.

 

51. G. Mokdsi and M.M. Harding,

Water Soluble, Hydrolytically Stable Derivatives of the Antitumour Drug Titanocene Dichloride and Binding Studies with Nucleotides,

J. Organometal. Chem., 1998, 565, 29-35.

 

52. M.M. Harding , G. Mokdsi, J.P. Mackay, M. Prodigalidad and S. Wright Lucas,

Interactions of the Antitumour Agent Molydocene Dichloride with Oligonucleotides,

Inorg. Chem., 1998, 37, 2432-2437.

 

53. A.C. Try, M.M. Harding, D.G. Hamilton and J.K.M. Sanders,

Reversible Five-Component Assembly of a [2]Catenane from a Chiral Metallomacrocycle and a Dinaphtho-crown Ether,

Chem. Commun., 1998, 723-724.

 

54. A.D.J. Haymet, L.G. Ward, M.M. Harding and C.A. Knight,

Valine Substituted Winter Flounder "Antifreeze": Preservation of Ice Growth Hysteresis,

FEBS Lett., 1998, 430, 301-306.

 

55. L. Painter, M.M. Harding and P.J. Beeby,

Synthesis and Interaction with human Serum Albumin of the First 3,18-Disubstituted Derivative of Bilirubin,

J. Chem. Soc., Perkin Trans. 1, 1998, 3041-3044.

 

56. G. Mokdsi and M.M. Harding,

Antitumour Metallocenes : Effect of DMSO on the Stability of Cp2TiX2 and Implications for Anticancer Activity,

Metal Based Drugs, 1998, 5, 207-215.

 

57. A.C. Try, L. Painter and M.M. Harding,

Rigid Chiral Carbocyclic Clefts as Building Blocks for the Construction of New Supramolecular Hosts,

Tetrahedron Lett., 1998, 39, 9809-9812.

 

97. Antifreeze glycoproteins: Design of mimics and interaction with membranes.

J. E. Stok, P. M. Abeysinghe, Y. Han, J. Garner, S. R. Inglis and M. M. Harding

Abstracts of Papers, 234th ACS National Meeting, 2007, American Chemical Society, Boston, MA, USA.

 

58. A.D.J. Haymet, L.G. Ward and M.M. Harding,

Winter Flounder ‘Antifreeze’ Proteins: Synthesis and Ice Growth Inhibition of Analogues that Probe the Relative Importance of Hydrophobic and Hydrogen-Bonding Interactions,

J. Am. Chem. Soc., 1999, 121, 941-948.

 

59. M.M. Harding, L.G. Ward and A.D.J. Haymet,

Why Fish Don't Freeze in Polar Waters,

Chem. in Aust., 1999, 31-33 (non-refereed).

 

60. M.M. Harding, L.G. Ward and A.D.J. Haymet,

Type I ‘Antifreeze’ Proteins : Structure-Activity Studies and Mechanisms of Ice Growth Inhibition,

Eur. J. Biochem., 1999, 264, 653-665.

 

61. M.C. Kimber, A.C. Try, L. Painter, M.M. Harding and P. Turner,

Synthesis of Functionalized Chiral Carbocyclic Cleft Molecules Complementary to Tröger's Base Derivatives.

J. Org. Chem., 2000, 65, 3042-3046.

 

62. M. Kimber, P.I. Anderberg and M.M. Harding,

Synthesis of ABC Analogues of Antitumor Antibiotic Streptonigrin,

Tetrahedron, 2000, 56, 3575-3581.

 

63. S. Wright Lucas and M.M. Harding,

Detection of DNA via an Ion-Channel Switch Biosensor,

Analytical Biochemistry, 2000, 282, 70-79.

 

64. G.V. Long, M.M. Harding and P. Turner,

X-Ray Structure of the Zinc Complex of the Central Metal Chelation Site of the Antitumour Drug Streptonigrin,

Polyhedron, 2000, 19, 1067-1071.

 

65. M.M. Harding and G. Mokdsi,

Antitumour Metallocenes: Structure-Activity Studies and Interactions with Biomolecules,

Current Medicinal Chemistry, 2000, 7, 1289-1303.

 

66.  M.M. Harding in Australian Chemistry Resource Book, Closet Chemistry : Is Your Home a Health Hazard, 2000, 19, 193-200; Ed. Fogliani, C. L. Bathurst, NSW. ISSN 1031-8305.

 

67. G. Mokdsi and M.M. Harding,

Inhibition of Human Topoisomerase II by the Antitumor Metallocenes,

J. Inorg. Biochem., 2001, 83, 205-209.

 

68. A.D.J. Haymet, L.G. Ward and M.M. Harding,

Hydrophobic Analogues of the Winter Flounder ‘Antifreeze’ Protein,

FEBS Letters, 2001, 491, 285-288.

 

69. G. Mokdsi and M M Harding

A 1H NMR Study of the Interaction of Antitumour Metallocenes with Glutathione

J. Inorg. Biochem. 2001, 86, 611-616.

 

70.  P. I. Anderberg and M. M. Harding

The Role of Ring D in the Antitumor Antibiotic Streptonigrin.  Metal Complexation, DNA Binding and Topoismerase II Inhibition of ABC Analogues of Streptonigrin.  

Anti-Cancer Drug Design, 2001, 16, 143-153.

 

71. P. I. Anderberg, M. M. Harding, I. J. Luck  and P. Turner

Ruthenium Complexes of Analogues of the Antitumor Antibiotic Streptonigrin

Inorganic Chemistry, 2002, 41, 1365-1371.

72. P. I. Anderberg, M. M. Harding and I. J. Luck

Assignment of the 13C and 15N NMR Spectrum of the Antitumour Antibiotic Streptonigrin

Magn. Reson. Chem., 2002, 40, 313-315.

 

73. E. Liepinsh G. Otting, M. M. Harding, L. G. Ward, J. P.Mackay and A. D.J. Haymet

Solution Structure of a Hydrophobic Analogue of the Winter Flounder Antifreeze Protein

Eur. J. Biochem. 2002, 264, 1269-1266.

 

74. J. D. Field, P. Turner, M. M. Harding, T. Hatzikominos and L. Kim

Chiral Carbocyclic Molecular Clefts Incorporating Hydrogen Bonding  Features

New J. Chem. 2002, 26, 720-725.

 

75. K. Fairley, B. J. Westman, Linda H. Pham, A. D. J. Haymet, M. M. Harding and J. P. Mackay

Type I Shorthorn Sculpin Antifreeze Protein : Recombinant Synthesis, NMR Spectroscopy & Ice Growth Inhibition Properties

J. Biol. Chem. 2002, 277, 24073-24080.

 

76. E. E. Bonfantini, A. K. Burrell, W. M. Campbell, M. J. Crossley, J. J. Gosper, M. M. Harding, D. Officer and D. C. W. Reid

Efficient synthesis of 2-formyl-5,10,15,20-tetraarylporphyrins, their reduction and conversion to [(porphyrin-2-yl)methyl]phosphonium salts

J. Porphyrins & Pthalocyanins, 2002, 6, 708-719.

 

77. A. R. Grummit, M. M. Harding, P. I. Anderberg and A. Rodger

Carbohydrate Derivatives of the Antitumour Alkaloid 9-Hydroxyellipticine

Eur. J. Org. Chem., 2003, 63-71.

 

78. A. R. Grummitt and M. M. Harding

9-Hydroxyellipticines and Derivatives as Chemotherapy Agents

Mini-Rev. Med. Chem., 2003, 3, 67-76.

 

79. M. M. Harding, P. I. Anderberg and A. D. J.Haymet

“Antifreeze” Glycoproteins from Polar Fish

Eur. J. Biochem., 2003, 270, 1381-1392.

 

80.  M . M. Tomczak, D. K. Hincha, J. H. Crowe, M. M. Harding and A. D. J. Haymet

The Effect of Hydrophobic Analogues of the type I winter flounder antifreeze protein on lipid bilayers

FEBS Lett., 2003, 551, 13-19.

 

81.  P.I  Anderberg, M.M. Harding and P. A. Lay

The effect of Metal Ions on the Redox Potential of the Antitumour Antibiotic Streptonigrin

J. Inorg. Biochem., 2004, 98, 720-726

 

82.  J. B. Waern and M.M. Harding

Coordination Chemistry of the Antitumor Metallocene Molybdocene Dichloride with Biological Ligands

Inorganic Chemistry 2004, 43, 206-213.

 

83. P. I. Anderberg, J. Turner, K. J. Evans, L. M. Hutchins and M. M. Harding

Ligand self-recognition in the stereoselective assmebly of [2+2] metallomacrocycles from racemic chiral bipyridyl molecular clefts and zinc(II)

Dalton Trans, 2004, 1708 - 1714.

 

84. M. M. Harding

Communication and Collaboration in Effective Supervision of Chemistry Postgraduates

Aust. J. Chem. Ed. 2004, 63, 5-10.

 

85. J. B. Waern and M. M. Harding

Bioorganometallic Chemistry of Molydocene Dichloride

J. Organomet. Chem. 2004, 689, 4655-4668.

 

86.  J. B. Waern, C.T. Dillon and M.M. Harding

Organometallic Anticancer Agents: Cellular Uptake and Cytotoxicity Studies on Thiol Derivatives of the Antitumor Agent Molybdocene Dichloride

J. Med Chem. 2005, 48, 2093-2099.

 

87.  A. Kwan, K. Fairley, P. I. Anderberg, C. W. Liew, M. M. Harding and J. P. Mackay

Solution structure of a recombinant type I sculpin antifreeze protein: the effects of supercooling and acetylation

Biochemistry 2005, 44, 1980-1988.

 

88.  J. B. Waern, H. Harris, B. Lai, Z. Cai, M. M. Harding and C. T. Dillon

Intracellular Mapping of the Distribution of Metals Derived from  the Antitumor Metallocenes

J.  Biol. Inorg. Chem., 2005, 10, 443-452.

 

89. J. J. Turner and M. M. Harding

Synthesis and properties of chiral molecular clefts related to Tröger's Base

Supramol. Chem., 2005, 17, 369-375.

 

90.  K. Campbell, A. J. Foster, C. T. Dillon and M. M. Harding

Genotoxicity and Transmission Electron Microscopy of Molybdocene Dichloride

J. Inorg. Biochem. 2006, 100, 1194-1198.

 

91. S. Inglis, J. J. Turner and M. M. Harding

Applications of Antifreeze Proteins: Studies with Model Membranes & Cryoprotectant Properties

Current Peptide and Protein Science, 2006, 7, 509-522.

 

92. C. K. Y. Lee, J. Groneman, P.Turner, L. M. Rendina and M. M. Harding

Synthesis and X-Ray Crystallographic Analysis of Chiral Pyridyl Substituted Carbocyclic Molecular Clefts

Tetrahedron 2006, 62, 4870-4878.

 

93.  J. B. Waern, P. Turner and M. M. Harding

Synthesis and Hydrolysis of Thiol Derivatives of Molybdocene Dichloride Incorporating Electron Withdrawing Substituents

Organometallics 2006, 25, 3417-3421.

 

94. S. Inglis, M. J. McGann, W. P. Price and M. M. Harding

Diffusion NMR Studies on fish antifreeze proteins and synthetic analogues

FEBS Letters 2006, 580, 3911-3915.

 

95. K. Campbell, C. T. Dillon, S. V. Smith and M. M. Harding

Radiotracer Studies of the Antitumor Metallocene Molybdocene Dichloride with Biomolecules

Polyhedron 2007, 26, 456-459.

 

96. P. M. Abeysinghe and M. M. Harding

Antitumor Bis(cylopentadienyl) Metallocenes: Titanocene and Molybdocene Dichloride and Derivatives

Dalton Trans. 2007, 3474 - 3482.; Featured in Chemical Biology, 2007, 9

 

97. Antifreeze glycoproteins: Design of mimics and interaction with membranes.

J. E. Stok, P. M. Abeysinghe, Y. Han, J. Garner, S. R. Inglis and M. M. Harding

Abstracts of Papers, 234th ACS National Meeting, 2007, American Chemical Society, Boston, MA, USA.

 

98.  J. Garner and M. M. Harding

Synthetic Mimics of a-Helical Peptides

Org. Biomol. Chem. 2007, 5, 3577 - 3585.

 

99. Inclusion Complexes of the Antitumour Metallocenes Cp2MCl2 (M=Mo, Ti) with Curcurbit[n]urils

D. P. Buck, P. M. Abeysinghe, C. Cuneene, A. J. Day, J. G. Collins and M. M. Harding

Dalton Trans. 2008, 2328 - 2334

 

100. J. Garner, S. R. Inglis, J. Hook, F. Separovic and M. M. Harding

A solid-state NMR study of the interaction of fish antifreeze proteins with phospholipid membranes

Eur. J. Biophys., 2008, 37, 1031-1038.

 

101. P. M. Abeysinghe, Y. Han and M. M .Harding

Oxidation of Threonine residues in Peptides with Hypervalent Iodine Reagents

Tetrahedron Letters., 2009, 50, 2601-2604.

 

102. J. Garner, K. A. Jolliffe, M. M. Harding and R. J. Payne

Synthesis of homogeneous antifreeze glycopeptides via a ligation-desulfurisation strategy

Chem. Commun. 2009, 6925-6927.

 

103. D. Schilter, J. K. Clegg, M. M. Harding and L. M. Rendina

Platinum(II) and Palladium(II) Metallacycles Derived from Cationic 4,4’-Bipyridinium, 3-Aminopyrazinium and 2-Aminopyrimidinium Ligands

Dalton Trans., 2010, 39, 239-247.

 

104.  L. Hunter, G. Condie and M. M. Harding

Reversible Aqueous Metathesis Chemistry for potential applications in dynamic combinatorial chemistry

Tetrahedron Lett. 2010, 51, 5064-5067.

 

105.  D. Schilter, T. Urathamakul, J. L. Beck, M. M. Harding, L. M. Rendina

ESI-MS and Thermal Melting Studies of DNA Interactions Involving Nanoscale Platinum(II) and Palladium(II) Metallomacrocycles

Dalton Trans.  2010, 39, 11263 - 11271.

 

106.  J. Garner and M. M. Harding

Design and Synthesis of Antifreeze Glyoproteins and Mimics

ChemBioChem. 2010, 11, 2489-2498.

 

107. C. Sherman Durai and M. M. Harding

Targeting Nucleic Acids Using Dynamic Combinatorial Chemistry

Aust. J. Chem. 2011, 64, 671-680.

 

 

PUBLISHED CONFERENCE ABSTRACTS

 

P.I. Anderberg, M. M. Harding

Streptonigrin analogues as potential anticancer agents

J. Inorg. Biochem. 2001, 86, 250.

J. B. Waern, C. T. Dillon, M. M. Harding

Interaction of Antitumour Metallocenes with Cellular Components

J. Inorg. Biochem. 2003, 96, 41.

J. B. Waern, C. T. Dillon, M. M. Harding

Towards the Determination of the Mechanism of Action of Molybdocene Dichloride

J. Inorg. Biochem. 2003, 96, 246.

 

Increased Cellular Uptake of the Antitumour Metallocene Molybdocene Dichloride

P. M. Abeysinghe, S. C- K. Lo, M. M. Harding, D. P. Buck and J. G. Collins

J. Inorg. Biochem. 2007, 12, S18.

 

Assembly of metallocyclic architectures: towards DNA nanoshuttles

D. Schilter, M. M. Harding and L. M. Rendina

J. Inorg. Biochem. 2007, 12, S105.

 

The Assembly of water-soluble nanoscale metallocycles as potential DNA nanoshuttles

C. Mulcahy, M. M. Harding and L. M. Rendina

J. Inorg. Biochem. 2007, 12, S147.

 

 

 

Updated: 26 April 2013/ Responsible Officer:  Director, RSC / Page Contact:  Webmaster