Synthesis & mechanism

The group’s activities continue to be focused on the development of new synthetic strategies and methodologies as well as the application of these in the total synthesis of biologically active natural products and certain analogues. Vinblastine (a binary indole-indoline alkaloid used in the treatment of early childhood leukaemia and bladder cancer), quinine (the famous anti-malarial alkaloid), various Amaryllidaceae alkaloids (eg lycorine, galanthamine and nobistiline A) and the potent new antibiotic platencin represent key targets and have inspired a considerable number of methodological studies. Australian industry has funded a significant portion of our work, while a new collaboration has just started with the German-based company BASF and is focused on developing novel agrochemicals based on marine natural products found in the cooler parts of the Southern Hemisphere oceans.

Publications

Personal Group Web Page

Updated:  22 November 2017/Responsible Officer:  Director, RSC/Page Contact:  Web Admin, RSC