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Biological chemistry involves the scientific study of the chemical processes in organisms. This area deals with the structure and function of cellular components, such as proteins, carbohydrates, lipids, nucleic acids, and other biomolecules.
The group develops novel tools for the application of NMR spectroscopy to the study of biological macromolecules (proteins and DNA). Emphasis is placed on the study of protein-protein, protein-DNA and protein-ligand interactions, with applications for drug development in the pharmaceutical industries in mind.
Our research interests lie at the interface between biology, chemistry and physics and are directed towards gaining an understanding of the fundamental chemistry that underlies biological function.
More about Chemical and Structural Biology
Structural bioinformatics is a highly cost-efficient solution for accelerated determination of the three-dimensional (3D) structure of proteins and protein-protein complexes from a minimal set of experimental data. The ultimate goal is to understand the delicately balanced, dynamic interactions between different molecules which form the basis of life and also offer key points for pharmaceutical intervention. The computational structural biology group develops innovative tools to determine the 3D structure of biological macromolecules form sparse experimental data of different length scale.
More about Computational Structural Biology
Our research is focused on the following three broad areas: the structure of complexes between DNA and anticancer antibiotics; the structure of unusual forms of DNA that have biological significance; and the structure and function of moderately sized proteins with a special focus on proteins that bind to DNA and RNA.
More about Nuclear Magnetic Resonance
We study how proteins function and investigate how they might be modified for new and useful purposes. Our group uses directed evolution to produce mutant proteins which are then screened for enhanced function or other interesting properties.
More about Protein Crystallography and Engineering
