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Biological chemistry involves the scientific study of the chemical processes in organisms. This area deals with the structure and function of cellular components, such as proteins, carbohydrates, lipids, nucleic acids, and other biomolecules.
The group develops novel tools for the application of NMR spectroscopy to the study of biological macromolecules (proteins and DNA). Emphasis is placed on the study of protein-protein, protein-DNA and protein-ligand interactions, with applications for drug development in the pharmaceutical industries in mind.
Our research is focused on the following three broad areas: the structure of complexes between DNA and anticancer antibiotics; the structure of unusual forms of DNA that have biological significance; and the structure and function of moderately sized proteins with a special focus on proteins that bind to DNA and RNA.
More about Nuclear Magnetic Resonance
We study how proteins function and investigate how they might be modified for new and useful purposes. Our group uses directed evolution to produce mutant proteins which are then screened for enhanced function or other interesting properties.
More about Protein Crystallography and Engineering
