Exploitation of cis-1,2-dihydrocatechol derivatives as starting materials for chemical synthesis

Supervisor contact

Related areas

The title compounds, which can be obtained by enantioselective microbial oxidation of the corresponding arene or through manipulation of the shikimic acid biosynthetic pathway, continue to serve as important starting materials for the preparation of a structurally diverse array of poly-oxygenated natural products and related structures. Methods for the enantiodivergent elaboration of cis-1,2-dihydrocatechols, through the application of various pericyclic processes, continue to be a major area of activity and some of the products derived from such reactions have been converted, using photochemically-promoted transformations, into the polycyclic skeleta associated with a diverse range of terpenoid natural products. Other natural products being targeted include the abovementioned alkaloids as well as the antibiotic platencin.

Updated:  21 October 2017/Responsible Officer:  Director, RSC/Page Contact:  Web Admin, RSC