Lanthanide-labelling of proteins

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Paramagnetic metal ions, in particular lanthanides, elicit large effects in NMR spectra which provide easily accessible long-range structural information. We are developing generic protocols for site-specific tagging of proteins with a lanthanide-binding peptide or organic molecule. We have developed the capability to incorporate unnatural amino acids site-specifically into proteins and are now working on selective reactions to append lanthanide-binding tags specifically to these amino acids.

Updated:  21 October 2017/Responsible Officer:  Director, RSC/Page Contact:  Web Admin, RSC