Summer research

Summer research scholarships provide insight into what studying for an Honours or higher degree by research is all about. You will be immersed in a challenging research environment, helping you to make an informed decision about your future study options.

ANU summer research scholarship

Monday 21 November 2016 to Friday 20 January 2017 inclusive (excluding christmas vacation: 24 December 2016 to 03 January 2017 inclusive).

A Summer Research Scholarship (SRS) will be awarded to eligible students from Australian or New Zealand Institutions. The SRS program will provide full-board accommodation (on-campus only), a weekly allowance of $500 per week, return travel to Canberra, and a short research project on an approved topic. The SRS program is available to 3rd, 4th & Honours year student who are currently enrolled at Universities in Australia or New Zealand, and are interested in pursuing an Honours program or Higher Degree by Research.

To apply please complete the online application form available at - Summer Research Scholarships website. Please indicate at least two supervisors, on your application form.

RSC summer research internship

Monday 21 November 2016 to Friday 20 January 2017 inclusive (excluding christmas vacation: 23 December 2016 to 03 January 2017 inclusive).

A Summer Research Internship (SRI) program will run concurrently with the Summer Research Scholarship program  - this program is for 2nd, 3rd, 4th & Honours Year ANU students only. The SRI program will provide a weekly allowance of $150 per week only.

To apply please complete the online application form available at - Summer Research Scholarships website. Please indicate at least two supervisors, on your application form.

If you have any questions please email rsc.hdr.sa@anu.edu.au.

Potential projects

Please contact academics to discuss alternative projects. They may be able to tailor projects to your particular interests.

Inorganic chemistry

Dr Nicholas White: Our research focuses on self–assembly – the construction of relatively large, complex species such as cages and frameworks through reversible interactions such as hydrogen bonding and halogen bonding. In particular, we are interested in anion-templated self–assembly – systems where positively-charged ligands are held together by anion templates. We are interested in both the fundamental aspects of this work: what kind of interesting and complex species can we make using this approach? as well as its potential applications: can we use our materials to bind organic pollutants? CO2 gas? This project will investigate the preparation of framework materials by anion templation. It will involve organic synthesis, studies of anion binding properties (by 1H NMR techniques), and X-ray crystallography. You do not need to have used any of these techniques before, but an enthusiasm for working out problems and making new things would be a definite plus! Email: nicholas.white@anu.edu.au for more information on specific projects.

Organic chemistry

Professor Martin Banwell: Synthesis and mechanism: A key focus of our research group is on the total synthesis of biologically active natural products and various analogues. The development of new methodologies that underpin such efforts is another focus and often involves the use of either, (i), strained organic molecules and reactive intermediates or, (ii), microbial oxidation products for such for such purposes. Medicinal chemistry based projects concerned with the development of orally available drugs for treating type-1 diabetes and certain neurological disorders as well as exploring the molecular basis of action of anti-mitotic drugs are being undertaken in collaboration with industry partners and/or overseas institutions. Email: martin.banwell@anu.edu.au for more information on specific projects.

Ass/Professor Mal Mcleod: Sports drug testing and medicinal chemistry: The McLeod group employs a wide range of techniques to study drug metabolism. These include chemical and enzymatic synthesis of drugs and their metabolites, methods of in vitro metabolism coupled with analysis by GC-MS-MS or LC-MS-MS, and molecular biology to engineer improved enzymes with anti-doping applications. The group is also active in the are of medicinal chemistry of nicotinic acetylcholine receptors (nAChRs). Here our goal is the development of new drugs to treat neurological disorders. Email: malcolm.mcleod@anu.edu.au for more information on specific projects.

Professor Mick Sherburn, Synthesis: my group aims to develop better ways to synthesise and study organic substances. Faster access to organic compounds – and a better understanding of organic structure and reactivity – leads to new and better medicines, smarter materials, and less environmental impact from chemical processes. We devise new domino reaction sequences and apply them in the shortest syntheses of biologically active natural products. We also devise the chemical synthesis of fundamental organic compounds that others have tried and failed to prepare. Overall, our goal is to advance the science of synthesis. For more information, see http://sherburngroup.org. For information on specific projects, contact Prof Mick Sherburn, michael.sherburn@anu.edu.au

Biological chemistry

Professor Thomas Huber: Projects are available in computational protein design and protein structure determination from sparse experimental data. We use computer algorithm to simulate and understand the principles of biomolecular structures. Combining this principle knowledge with easy to perform experiments we then computationally determine the structure of proteins, or design completely new proteins with novel functions. Email t.huber@anu.edu.au for more information on specific projects.

A/Professor Colin Jackson: We  are interested in protein engineering, design and evolution. There are a number of research programs in the lab that you could be part of: (1) understanding the molecular basis of evolution through ancestral protein reconstruction, where we computationally predict the sequence of ancient proteins, to understand how mutations have led to the multitude of functions we see today; (2) understanding the role of protein dynamics to function, especially in enzymes, and how this can be changed through evolution/engineering; (3) the design and engineering of a new family of oxidoreductases for biocatalysts and use in the production of fine chemicals and pharmaceuticals; (4) the design and construction of new biosensors for neurotransmitters; (5) understanding the molecular basis of insecticide resistance and designing new pesticides; (6) computational design of new inhibitors for a drug target involved in cancer. Email: colin.jackson@anu.edu.au for more information on specific projects.

Professor Gottfried Otting: Zika protease: Analysing structure changes by NMR. The Zika virus critically depends on its NS2B/NS3 protease for proliferation. The Otting group has experience with the corresponding proteases from dengue and West Nile virus (refs 1-5). The Zika protease is a key drug target. In this project, the student will join our efforts in analysing the structural changes in the Zika protease in solution by NMR spectroscopy as a basis for drug development. Techniques used include cell-free protein synthesis, site-directed mutagenesis, lanthanide tagging of cysteine residues and NMR spectroscopy. Email: gottfried.otting@anu.edu.au for more information on specific projects.

Professor John Carver: Our research interests are in peptide and protein structure, function and interactions. Of late, the group has been concentrating on molecular chaperone proteins and their mechanism of stabilizing other proteins, particularly those involved in diseases of protein aggregation, e.g. Alzheimer’s and Parkinson’s diseases and cataract. Another area of interest involves examination of the oligomeric structure of milk proteins, particularly the caseins, a topic of fundamental importance to the fields of dairy science and nutrition. We utilise a diversity of spectroscopic, biophysical and protein chemical techniques for our research, with NMR spectroscopy being at the forefront. Email:john.carver@anu.edu.au for more information on specific projects.

Dr Megan O'Mara: "Characterising protein-protein and protein-lipid interactions in amyloid plaque formation" -  Amyloid beta (Aβ) peptide is the main component of amyloid plaques found in the brains of Alzheimer patients. While the physiological function of Aβ peptide is unknown, it is known to be an extremely flexible intrinsically disordered protein that undergoes a conformational change in response to environmental conditions. The amyloidogenic oligomers are believed to be primarily b sheet structures, while the soluble form is believed to be predominantly helical. Aβ peptides also adopt a variety of conformations on binding to phospholipids membranes of different lipid composition. Intriguingly, recent studies have indicated that the human multidrug transporter, P-glycoprotein, is involved in the export of Aβ peptide from neuronal cells, suggesting that it plays a role in the accumulation of the amyloid-forming Ab42 peptide. At present there is no information regarding how Ab peptide interacts with or is transported by P-glycoprotein. The objective of this project is to understand the spectrum of conformations Ab42peptide adopts in solution, and how it interacts with P-glycoprotein within a cholesterol-rich phospholipid raft environment. NOTE: this project is a computational project. No previous computational experience is required, although students should have some background in physical chemistry and/or structural biochemistry. Email: megan.o'mara@anu.edu.aufor more information on this project.

Physical and theoretical chemistry

Dr Pierre-Francois Loos: "Development of new density functional approximations for molecules and solids" - The purpose of this exciting project is to create a new, improved density functional approximation [1] that can be used to accurately calculate the electronic properties of molecules and solids [2, 3]. During this project, the student will have the opportunity to explore the basics of quantum mechanics and discover state-of-the-art computational techniques, such as Quantum Monte Carlo (QMC) [4]. In particular, the student will learn how to use the CASINO software to perform QMC calculations [5]. Variational Monte Carlo (VMC) and diffusion Monte Carlo (DMC) calculations will be required to obtain high-accuracy correlation energies for finite uniform electron gases [6]. This will involve large-scale parallel calculations. All these calculations will be performed on the NCI supercomputer. These results will be used to create a generalised version of the localdensity approximation [1]. Email: pf.loos@anu.edu.aufor more information on this project.

Material science

Professor Yun Liu: "Wet chemical synthesis of metal oxide composites" - This project aims to synthesize  crystalline nano particles for further fabrication of a new composite  that gives an excellent dielectric property for use in electronic devices. The student will  be trained in the field of materials chemistry, including wet chemical synthesis approach, structural analysis, microstructural characterisation and physical property measurement, and thus gains the knowledge and skills for further study as a honours student or  PhD student in this field.  A background in Materials Chemistry is essential. Additional background in Applied Physics and/or Materials Science as well as Applied Mathematics is preferred. Email: yun.liu@anu.edu.au for more information on this project.

Updated:  01 May 2017/Responsible Officer:  Director, RSC/Page Contact:  Web Admin, RSC