Reaction discovery via novel intermediates.

 

ABSTRACT

It's a well known adage in chemistry that structure defines function. One way to access new structure, and hence new function, is to first look for

new reactivity. In this talk, I will present three projects which demonstrate this concept of reactivity driven reaction discovery. This will include the first known

reaction catalysed by a stable, monomeric palladium(I) complex, to achieve highly selective oxidative cross-coupling between nucleophiles. We will also see the

development of new reactivity in Lewis base catalysis for the synthesis of complex molecules, and the application of C-S bond activation and radical decarboxylation

for the functionalisation of polymers.