Dr Adam Carroll

Joint Mass Spectrometry Facility Manager

Dr Carroll has been engaged in mass spectrometry-based research since 2005. His PhD, awarded in 2010, was completed at the University of Western Australia under the co-supervision of plant scientist and proteomics specialist, Prof Harvey Millar, and the late natural products chemist, A/Prof Emilio Ghisalberti. His PhD research focused on mass spectrometry based proteomics, metabolomics and mass spectrometry data analysis software development. During his PhD, he developed MetabolomeExpress – one of the world’s first online mass spectrometry data processing pipelines and public data repositories to facilitate the efficient and transparent processing, sharing and re-use of mass spectrometry metabolomics datasets. These tools were applied to: 1) the proteomic characterisation of plant ribosomes, including the elucidation of novel post-translational modifications; and 2) the metabolomic analysis of plant responses to environmental and genetic perturbations, particularly focused on abiotic stress and perturbations of aerobic respiration pathways. Dr Carroll moved to the ANU as a post-doctoral plant scientist in the laboratory of Professor Murray Badger where he set up the ANU’s first high throughput GC/MS metabolomics platform, established a cutting-edge robotics facility for high-throughput preparation of biological samples and integrated forward genetic screening, next-gen genome sequencing and metabolomics to hunt for novel genes involved in plant photorespiration. An output from this project was PhenoMeter – the world’s first metabolome database search using metabolic phenotypes as queries to identify similar phenotypes in other studies (like a BLAST search for metabolic phenotypes). In 2015, he moved to the laboratory of Prof Guillaume Tcherkez to study plant biochemical responses to CO2, O2 and light using a range of techniques including metabolic labelling with 13CO2. He began as Manager of the JMSF in May 2017 where he continues to provide training and support and develop hardware and software tools to facilitate cutting-edge mass spectrometry-based research.