A comprehensive overview of academic research, members and new potential projects.

Anti-doping and medicinal chemistry »

This group employs a wide range of techniques to study drug metabolism. These include chemical and enzymatic synthesis of drugs and their metabolites, methods of in vitro metabolism coupled with analysis by GC-MS-MS or LC-MS-MS, and molecular biology to engineer improved enzymes with anti-doping applications.

Biochemical reactions & molecular recognition »

We analyse chemical reactions, particularly those occurring in biochemical systems, in order to develop new synthetic methods and to produce physiologically active compounds with potential as pharmaceuticals.

Biomolecular NMR spectroscopy »

We work with drug discovery, developing new methods to analyse the structures of protein-ligand complexes in solution by NMR spectroscopy.

Biomolecular simulation and dynamics »

Our research lies at the interface of chemistry, physics and biology. Using cutting-edge computational techniques, we examine the underlying dynamic interactions between proteins, phospholipids and ligand molecules to provide the link between the structure of a protein and its biological function.

Catalyst Design »

We aim to address challenges in sustainability through the development and understanding of effective homogeneous transition metal catalysts.

Chemical & structural biology »

Our research interests lie at the interface between biology, chemistry and physics and are directed towards gaining an understanding of the fundamental chemistry that underlies biological function.

Computational quantum chemistry »

We use quantum chemical methods, primarily Density Functional Theory (DFT), to explore the molecular structure, bonding and reactivity of chemical systems, particularly those involving transition metal ions.

Computational structural biology »

The computational structural biology group develops innovative tools to determine the 3D structure of biological macromolecules form sparse experimental data of different length scale.

Computer-aided chemical design »

We work in the fast-growing field of computer-aided chemical design. We use state-of-the-art quantum chemistry calculations to identify and explain the mechanism, kinetics and thermodynamics of complicated multi-step chemical processes - information that is difficult (often impossible) to obtain via experiment alone.

Functional materials »

Our work is mainly concentrated on the interaction amongst synthesis, micro-structure and polarisation-related properties of functional materials.

Materials and New Technologies for Battery Storage »

Our research is focused on developing materials and technologies for energy storage in batteries and related devices. A particular focus is on beyond-lithium batteries such as sodium-ion, potassium-ion and dual-ion batteries.

Materials Science and Applications »

The group is interested in synthesis & understanding of nano-to-atomic materials & structures, applications development for sustainable functional devices, and rational advancement towards multi-functions integrated systems. 

Medicinal & Natural Systems Chemistry »

Our research uses organic synthesis techniques to create molecules for application in medicinal chemistry and plant sciences.

Medicinal Chemistry & Bioconjugation »

We create and study selective interactions between proteins and small synthetic molecules. Our research projects are interdisciplinary.

Molecular and Magnetic Spectroscopy »

Our group studies transition metal catalysts using both magneto-optical spectroscopy and magnetic resonance techniques. These methods can be used to monitor: oxidation states, transients/intermediates, the binding of substrates as well as product formation and release, providing important complementary information to static spectroscopic and diffraction methods.

Natural and Artificial Photosynthesis »

We are studying fundamental processes in both natural and artificial photosynthesis with the goal of utilizing solar energy as a source of storable energy to replace coal and oil.

Organic synthesis and chemical biology »

Our research lies at the interface of organic chemistry and chemical biology. We aim to develop versatile new synthetic tools for small molecule synthesis, protein bioconjugation, and the design of peptide-based therapeutics.

Organometallic chemistry & molecular materials »

The aim of our research is the preparation of new types of potentially useful molecular materials. Understanding how chemical structure can control molecular properties is the key step, and this necessitates coupling chemical synthesis to a range of physical properties studies.

Photophysical Chemistry of Materials »

Our research mainly focuses on the interaction between light and chemicals and its application in materials sciences. We also investigate the relevant photophysical chemistry in the processes which can be theoretical guidance for the optimization design of high-performance systems.

Polymers & soft condensed matter »

This group is interested in the physical chemistry of soft matter, as for example, the behavior of single molecule machines, such as rotaxanes, or the mobility of colloids near a liquid interface or membrane surface, or the properties of polymer brushes. 

Protein structure, function and interactions »

We use a variety of spectroscopic, biophysical and protein chemical techniques to study molecular chaperone proteins and their mechanism of stabilising other proteins.

Supramolecular chemistry »

Our research focuses on supramolecular chemistry – the chemistry of non-covalent interactions such as hydrogen bonding, halogen bonding and coordination bonds. 

Sustainable Biocatalysis & Molecular Diagnostics »

Through novel approaches at the interface of Synthetic Biology and chemistry we seek to create real-world solutions to some of the most pressing issues: Global Health & Biosecurity, Chemical & Energy Sustainability. 

Synthesis »

Our research program involves the design and implementation of sequences of cycloaddition reactions, free radical reactions and transition metal-mediated reactions to prepare polycyclic molecules with important biological properties.

Synthesis & mechanism »

The group’s activities continue to be focused on the development of new synthetic strategies and methodologies as well as the application of these in the total synthesis of biologically active natural products and certain analogues.

Synthetic Biology »

Our multidisciplinary research looks at the design of new biological parts or systems.

Synthetic organometallic & coordination chemistry »

Our work covers a diversity of challenges in coordination and organometallic chemistry. Particular foci include unsaturated ligands involving metal–carbon multiple bonding and the interface of transition and main group chemistries.

Synthetic Polymer Chemistry »

At the Connal group we make polymers. Polymers and soft matter have a number of applications across a multitude of industries and areas which means we develop new materials for a range of applications.

Theoretical quantum chemistry »

Quantum chemistry is the discipline in which the laws of quantum mechanics are applied to understand and predict molecular behaviour.