We work with drug discovery, developing new methods to analyse the structures of protein-ligand complexes in solution by NMR spectroscopy.
We use cell-free protein synthesis as one of our main tools and have leading expertise in the use of unnatural amino acids for site-specific protein modification (for example with tags that allow rapid determination of the binding site, binding orientation and structure of ligand molecules).
Research support officer
|Assessing potential inhibitors against the NS2B-NS3 dengue virus protease||Current|
|Cell-free protein synthesis||Potential|
|Development of paramagnetic NMR as a new tool for drug discovery||Potential|
|Discovering inhibitors against the penicillin-degrading enzyme IMP-1||Current|
|Lanthanide-labelling of proteins||Potential|
|Multi-dimensional NMR spectroscopy||Current|
|Protein structure determinations||Potential|