McLeod Group

The McLeod group employs a wide range of techniques to study drug metabolism. These include chemical and enzymatic synthesis of drugs and their metabolites, methods of in vitro metabolism coupled with analysis by GC-MS-MS or LC-MS-MS, and molecular biology to engineer improved enzymes with anti-doping applications.

The group is also active in the area of medicinal chemistry of nicotinic acetylcholine receptors (nAChRs). Here our goal is the development of new drugs to treat neurological disorders and the application of tools like covalent trapping, an extension of the substituted cysteine accessibility method, to better understand where drugs bind on nAChRs.


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