Antibiotic resistance and bacterial efflux pumps

Superbugs, or multidrug resistant bacteria, are an impending global health crisis. One mechanism of resistance to multiple antibiotics is through the expression of multidrug transport proteins, which efflux broad-spectrum antibiotics such as aminoglycosides, macrolides and tetracyclines. The mechanism of drug transport in bacterial multidrug efflux proteins is poorly characterised. This project will examine structure-function relationships of multidrug transporters, including ATP-Binding Cassette (ABC) transporters, major facilitator superfamily (MFS), antimicrobial extrusion (MATE) transporters, small multidrug resistance (SMR) proteins, and the resistance/nodulation/cell division (RND) superfamily.