Chemoselective ligation tools for the synthesis of proteins and antibody-drug conjugates

Chemical protein synthesis provides unlimited flexibility for the design of engineered protein variants for the advancement of biological, medicinal, and materials science. Synthetic methods rely on our ability to precisely stitch together short peptide fragments in the presence of the diverse array of proteinogenic amino acid side-chains. We aim to explore versatile new chemical ligation strategies for the construction of native protein targets and discrete structural analogues. Such methodologies will extend the therapeutic potential of proteins and facilitate a greater understanding of the link between protein structure and function.