Post-synthetic modification of supramolecular assemblies

The assembly of supramolecular complexes often necessitates very particular reagents and conditions that limits the scope of the chemistry possible with them. The design of supramolecular species bearing functional groups or labile ligands that are inert to the conditions of their initial assembly, but can be later transformed via post-synthetic modification, are of great interest as a way of tuning steric and electronic properties of supramolecular scaffolds. As some supramolecular species cannot be directly synthesised, this methodology also increases the scope of potentially accessible architectures we can create.