Strategies for the late-stage modification of peptides and proteins

Peptides and proteins are implicated in a multitude of crucial biological processes. The functional diversity of these molecules stems not only from the variety of canonical amino acids, but also the enzymatic decoration of native side-chains with structurally diverse post-translational modifications. Synthetic strategies which precisely tailor the structure and function of peptide and protein targets allow us to extend the biological diversity of these important biomolecules. We are interested in the development of residue-specific, late-stage modifications, including new strategies for protein bioconjugation, unnatural amino acid incorporation, and radiolabeling.