Aiming For The Perfect Chemical Synthesis

To devise better ways to make complex molecules, we are inventing powerful domino reactions, which are spectacular ways to create complex molecules in the quickest possible way. 

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Important organic molecules such as medicines are traditionally made in a cumbersome way. Chemists either build them from scratch or take a related molecule and renovate it. It is always a lengthy process, with unwanted structural features being ripped out and replaced, which is wasteful and inefficient. The ideal chemical synthesis involves a single step process that converts simple and inexpensive building blocks into complex and valuable products, in an environmentally benign manner. To devise better ways to make complex molecules, we are inventing powerful domino reactions, which are spectacular ways to create complex molecules in the quickest possible way. 

We used our new method to make pseudopterosin, a powerful anti-inflammatory and analgesic drug, which is currently only available in tiny quantities extracted from fan coral found in the Bahamas. While it is the most efficient synthesis so far, it is not perfect, so we’re looking to devise even more powerful domino reactions for the next generation of chemical syntheses.

Aiming For The Perfect Chemical Synthesis
Aiming For The Perfect Chemical Synthesis