Free radical reactions of amino acids, peptides and proteins

We are investigating the free radical reactions involved in the secondary metabolism of amino acids and peptides. The insights gained are being used to develop enzyme inhibitors to regulate the biosynthesis of peptide hormones and treat diseases associated with the over-production of these hormones. We are also designing amino acids for incorporation into peptides to make them resistant to free radical and oxidative degradation. Other results are being applied to develop more efficient methods for synthesising peptides.