New synthetic strategies and methodologies

The electrocyclic ring-opening of ring-fused gem-dibromo- and gem-dichloro-cyclopropanes continues to be employed in a wide variety of contexts, with one especially notable activity being focused on the construction of the polycyclic frameworks associated with a range of alkaloids. The exploitation of pyrroles and indoles as nucleophilic scaffolds for the construction of various alkaloids also remains a major activity within the group. Certain work in this area has focused on attempts to mimic the key bond-forming events associated with the proposed biogenesis of the marine alkaloids known as the lamellarins.