News & Events Events RSC School Seminar - Assoc. Prof. Mehdi Mobli (UQ) Title: New directions in structural studies of ion channels and their modulation by disulfide-rich peptides schedule Date & time Date/time 25 Mar 2021 | 12pm next_week Event series Event series RSC Seminar Series contact_support Contact Amelia Daveyrsc.admin@anu.edu.au Content navigation toc Description Title: New directions in structural studies of ion channels and their modulation by disulfide-rich peptides Speaker: Assoc. Prof Mehdi Mobli Ion channels and their structural relatives comprise one of the largest superfamilies of signal transduction proteins. Unsurprisingly, these ion channels are also among the most common drug targets. Ion channels, however, have proven particularly recalcitrant to traditional drug discovery approaches and our work seeks to address this through improved understanding of the structure and function of these channels. Animal venoms have proven a rich source of ion-channel modulators, eliciting diverse pharmacological responses in their target hosts. Disulfide-rich peptides, within venoms, are of particular interest as they often act through an allosteric mechanism that capture elusive states of ion channels – important both pharmacologically and in improving our understanding of channel function. I will present recent work from our group, including (1) engineering a new system for generating lipid bilayer nanodiscs (2) bivalent peptide discovery efforts, as well as (3) our work on understanding the structural basis of peptide binding to cell memrbanes and ion channel receptor sites. Location Join Zoom Meeting https://anu.zoom.us/j/87050477742?pwd=NUhKcjZPNVhpZkIzYjFCVWxHMURBUT09 Meeting ID: 870 5047 7742 Password: 653830 Upcoming events in this series 18 Apr 2024 | 12 - 1pm RSC School Seminar - A/Prof Hendrik Frisch (Queensland University of Technology) Title: Synthesis of Synthetic and Peptide-Based Macromolecular Architectures for Interactions with Light View the event