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Organosilicon functional groups in photochemical synthesis and transition-metal catalysis

Abstract

Acylsilanes represent a valued functional group in chemical synthesis due to their capacity to react as electrophiles, acyl radical precursors or as nucleophilic carbene precursors upon irradiation with visible light. We have also recently demonstrated that acylsilanes can be engaged as weakly coordinating direct groups to achieve site selective C-H functionalization under Rh(III) or Co(III) catalysis. Building on this work, recent efforts within our group that have focused on the development of combined C-H functionalisation/photochemical protocols to access a variety of valuable molecular frameworks will be presented.

Biography

Dr Dan Priebbenow completed his PhD in Chemistry at Deakin University following studies into palladium-catalysed domino reactions. Dan was subsequently awarded an Alexander von Humboldt Postdoctoral Fellowship at the Institute of Organic Chemistry, RWTH Aachen University in Germany. After returning to Australia, Dan spent several years as a research fellow within the Australian Translational Medicinal Chemistry Facility at Monash University’s Institute of Pharmaceutical Sciences (MIPS). In 2020, Dan started his independent career within the School of Chemistry at the University of Melbourne as an ARC DECRA Fellow before returning to MIPS (Monash University) where he is now Senior Lecturer and Deputy Leader in the Medicinal Chemistry Theme. Dan's research is currently focused on the discovery and application of new synthetic technologies.