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Nickel Phosphite Precatalysts for C-S C-C and C-N Bond Formation

Abstract

Nickel complexes are increasingly being developed as catalysts for cross-coupling reactions as a reactive and cost-effective alternative to palladium catalysts. In this presentation the rational design and synthesis of new inexpensive air-stable nickel phosphite based catalysts will be discussed. Additionally, their application in C-N, C-S and C-C coupling reactions will also be revealed. The yields using these nickel precatalysts are often improved or comparable with those achieved using Ni(COD)₂. This presentation will also show the physical and chemical properties these nickel complexes as well as provide some emphasis on mechanistic concepts.

References:

1 S. S. Kampmann, A. N. Sobolev, G. A. Koutsantonis, S. G. Stewart, Adv. Synth. Catal. 2014, 356, 1967.

2. K. D. Jones, D. J. Power, D. Bierer, K. M. Gericke, S. G. Stewart. Org. Lett., 2018, 20, 208.

3. J. Duczynski, A. N. Sobolev, S. A. Moggach, R. Dorta, S. G. Stewart Organometallics 2019, 39, 105.