Contacts
Gottfried Otting received his Diploma of Chemistry from the University of Freiburg and completed his PhD at ETH-Zürich. He has since held positions at ETH-Zürich (1987-1992) and became Professor at the Karolinska Institute (1992-2002) before his appointment as a Professor and Federation Fellow (2002-2007) at the Research School of Chemistry.
He was awarded the Latsis prize of the ETH-Zürich (1992), the FEBS Anniversary Prize (1993), the Wallmarkska Prize of the Royal Swedish Academy of Sciences (1996), the Alexander von Humboldt Research Award (2010), and he is a foreign member of the Latvian Academy of Sciences (2006).
Group web site
http://rsc.anu.edu.au/~go/index.html
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International Society for Magnetic Resonance (ISMAR) Fellow , 16 November 2020
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FEBS Anniversary Prize of the Gesellschaft für Biologische Chemie, 16 November 2020
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Australian Laureate Fellowships, 3 November 2020
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ANZMAG Medal, 1 July 2013
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Humboldt Research Award , 1 November 2010
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ARC Federation Fellowship, 16 November 2002
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Wallmarkska Prize of the Royal Swedish Academy of Sciences , 1 November 1996
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Latsis Prize of the ETH-Zürich , 16 November 1992
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ETH Medal, 26 October 1987
Research interests
Development of NMR methods for drug development. In particular, site-specifically attached paramagnetic tags (using unnatural amino acids) are employed to identify the binding site, binding orientation and structure of low-molecular weight compounds on protein targets in solution. Currently, this strategy is being established as a tool for fragment-based drug design.
The same tags are deployed to monitor proteins ‘in action’, i.e. as they change their structure during their functional cycle, and to determine the interactions between different proteins.
As a spin-off, pairs of the paramagnetic tags are used to measure accurate distances in proteins by EPR spectroscopy in collaboration with Prof. Daniella Goldfarb (Israel).
Groups
- Leader, Otting Group
