Research Research groups Otting Group toc We use NMR spectroscopy to assess the structural changes of proteins in response to other molecules in aqueous solution, i.e. under near-physiological condition label Research theme Research themes Physical and Biophysical Chemistry About We work with drug discovery, developing new methods to analyse the structures of protein-ligand complexes in solution by NMR spectroscopy. We use cell-free protein synthesis as one of our main tools and have leading expertise in the use of unnatural amino acids for site-specific protein modification (for example with tags that allow rapid determination of the binding site, binding orientation and structure of ligand molecules). Projects NMR spectroscopy/ Playing tag with proteins The group develops techniques to attach chemical tags to proteins site-specifically, to enable convenient analysis by NMR and EPR spectroscopy. This includes the use of cell-free protein synthesis with bespoke unnatural amino acids and specific labelling techniques. More at rsc.anu.edu.au/~go/index.html Read more Student intake Open for Honours, PhD students Theme Physical and Biophysical Chemistry Read more Members Leader Prof. Gottfried Otting ARC Laureate Fellow Researcher Mr Elwy Abdelkader Ali Postdoctoral Fellow Dr. Michael Maxwell Postdoctoral Fellow Dr Adarshi Welegedara Postdoctoral Fellow Student Kasuni Bhagya Ekanayake Haluwadana Ralalage G. W. PhD Candidate Inoka (Dilhara) Herath PhD Candidate Yi Jiun Tan PhD Candidate News Incorporating an Unnatural Amino Acid To Improve NMR - JACS Spotlight Spotlights on Recent JACS Publications has highlighted a JACS paper recently published by Elwy Abdelkader, Haocheng Qianzhu, Yi Jiun Tan, Luke Adams, Thomas Huber and Gottfried Otting (10.1021/jacs.0c11971). Read the article toc
