Playing tag with proteins

This is one of the big unsolved challenges in biochemistry: how to direct the tag to a single site, ideally inside cells in the presence of other proteins and cell metabolites. The project employs unnatural amino acids for the attachment of fluorophores, EPR tags and NMR tags.

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This project is open for Honours, Master, PhD and Summer scholar students.
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Contact name
Gottfried Otting
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How can the essential features of a protein be analysed quickly? Attach a tag! In this project, we develop new methods
by which chemical tags can be attached specifically to single selected sites. This is one of the big unsolved challenges
in biochemistry: how to direct the tag to a single site, ideally inside cells in the presence of other proteins and cell
metabolites. The project employs unnatural amino acids for the attachment of fluorophores, EPR tags and NMR tags.

Playing tag with proteins