chemical and systhetic biology

Chemical and Synthetic Biology

Chemical and Synthetic Biology combines chemistry, molecular engineering and biology to understand and redesign living systems for pharmaceutical, agricultural and industrial applications.

About

Chemical and Synthetic Biology is an interdisciplinary field that uses chemical tools, molecular design and engineering principles to study, manipulate and understand biological systems. It develops chemical probes, synthetic molecules and molecular technologies to investigate biological processes and control cellular function. Research in this area at the RSC spans protein/peptide engineering and evolution, structural and mechanistic studies of biomolecules, analytical and biophysical characterisation, and the development of cell-free and cell-based platforms for pharmaceutical, agricultural and industrial applications. RSC jointly hosts the ANU SynBio Initiative, and ANU nodes of 3x ARC Centres of Excellence including ‘Synthetic Biology’, ‘Innovations in Peptide and Protein Science’ and more recently ‘Advanced Peptide and Protein Engineering’. This research is supported through substantial competitive funding from the Australian Research Council (ARC), National Health and Medical Research Council (NHMRC), Grains Research and Development Corporation (GRDC) and the Snow Medical Research Foundation.

Projects

Developing new chemical synthesis strategies to control the folding of complex 3D peptide topologies, unlocking bioactive molecules from Australia's unique biodiversity including venom peptides.

Student intake

Open for Bachelor, Honours, Master students

Designing peptides and small proteins that bind cancer-cell receptors and diagnostic or therapeutic radiometals directly, without large chelators, for use in cancer theranostics.

Student intake

Open for Bachelor, Honours, Master students

Designing metallopeptoid biomimetic catalysts using non-endogenous metals, building on our discovery that short metal-binding peptides act as mini-enzymes with Michaelis-Menten kinetics.

Student intake

Open for Bachelor, Honours, Master students

This project is expected to protect important agriculture crops with a novel class of chemical fungicides, contributing to global food security and delivering substantial environmental benefits

Student intake

Open for Bachelor, Honours, Master, PhD students

This project will contribute to a broader research endeavour in the Zhang lab which aims to establish a synthetic biology toolbox towards safe and sustainable control of fungal diseases in agriculture and in native ecosystems

Student intake

Open for Bachelor, Honours, Master, PhD students

People

This project uses synthetic biology and directed evolution to study immune receptor proteins in plants and animals, uncovering their structural and biochemical mechanisms to inform therapeutic targets and develop disease-resistant crops.

Student intake

Open for Bachelor, Honours, Master, PhD students