Building Complex Peptide Topologies

Nature has evolved bioactive peptides with precisely folded 3D structures that underpin their remarkable functions. Recreating these complex shapes in the laboratory remains a major challenge, as peptides can easily misfold and lose their activity. We are developing new chemical synthesis strategies to control the assembly of 3D peptide topologies (a process known as folding) and unlock bioactive molecules from Australia's unique biodiversity, including venom peptides from spiders and snakes. This project will involve the chemical synthesis, folding and structural analysis of complex peptides using NMR spectroscopy, with potential applications in drug discovery and the development of biotechnological tools.