Protein infection

Nitsche Group

We develop chemical tools to target, manipulate and study peptides and proteins related to infectious diseases.

label Research theme

About

We create and study selective interactions between proteins and small synthetic molecules. Our research projects are interdisciplinary. We apply chemical and physical tools to address questions of biological and medicinal relevance, involving a broad spectrum of techniques ranging from organic chemistry to structural biology.

We aim to accelerate the drug discovery process by introducing new technology platforms, develop anti-infective agents and establish novel chemical ligation reactions that do not interfere with biological systems.

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Projects

Infectious viruses such as dengue, Zika, West Nile, Chikungunya or SARS-CoV-2 have common Achilles heel: their protease. Proteases are key enzymes of viral replication and promising drug targets. The project explores constrained peptides targeting proteases available in our lab from flavi-, alpha- and coronaviruses

Student intake

Open for Honours, PhD students

Theme

Medicinal Chemistry and Drug Development, Organic chemistry

This project aims to advance the development of specific antiviral drugs targeting SARS-CoV-2 infections.

Student intake

Open for Honours students

Members

Leader

Associate Professor Christoph Nitsche

Associate Professor
ARC Future Fellow

Student

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PhD Candidate

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Honours Student

MPhil Candidate

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Honours Student

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PhD Candidate

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PhD Candidate

News

Researchers at RSC have developed a new way to synthesise bicyclic peptides, with major implications for future research into drug treatments for a range of diseases including cancer, viruses and bacterial infections.

Read the article