Structural bioinformatics is a highly cost-efficient solution for accelerated determination of the three-dimensional (3D) structure of proteins and protein-protein complexes from a minimal set of experimental data. The ultimate goal is to understand the delicately balanced, dynamic interactions between different molecules which form the basis of life and also offer key points for pharmaceutical intervention. The computational structural biology group develops innovative tools to determine the 3D structure of biological macromolecules form sparse experimental data of different length scale.