Research Research groups Huber Group The Huber group develops innovative tools to determine the 3D structure of biological macromolecules form sparse experimental data of different length scale. label Research theme Research themes Computational and Theoretical Chemistry Physical and Biophysical Chemistry About Structural bioinformatics is a highly cost-efficient solution for accelerated determination of the three-dimensional (3D) structure of proteins and protein-protein complexes from a minimal set of experimental data. The ultimate goal is to understand the delicately balanced, dynamic interactions between different molecules which form the basis of life and also offer key points for pharmaceutical intervention. The computational structural biology group develops innovative tools to determine the 3D structure of biological macromolecules form sparse experimental data of different length scale. Publications Personal Group Web Page Projects Continuous Molecular Evolution This project will make further improvements to targeted gene mutagenesis and apply continuous molecular evolution to enhance specific binding of proteins to their respective targets. Read more Student intake Open for Honours, Master, PhD, Summer scholar students Read more Deep Learning to Predict Structure and Function of Proteins This project will train and apply variational autoencoders to i) predict compatibility between protein sequence and structure, and ii) rationalize and predict function of aminoacyl-tRNA synthetases from library sequence data. Read more Student intake Open for Honours, Master, PhD, Summer scholar students Theme Computational and Theoretical Chemistry Read more Detecting protein complexation in cells using High-Field Electron Paramagnetic Resonance This project aims to magnetically label proteins for new electron paramagnetic resonance (EPR) experiments to study a protein’s structure and dynamics at low concentrations and in-cell. Read more Student intake Open for Honours, Master, PhD, Summer scholar students Theme Physical and Biophysical Chemistry Read more Making Better Proteins with Un-natural Amino Acids This project will engineer new aminoacyl-tRNA synthetases to genetically encode un-natural amino acids with unusual chemical properties and apply them to produce valuable designer proteins for medicine, biotechnology and synthetic biology. Read more Student intake Open for Honours, Master, PhD, Summer scholar students Read more Methods for Protein Structure Analysis by Electron Paramagnetic Resonance This project will magnetically label proteins for new electron paramagnetic resonance (EPR) experiments to study a protein’s structure and dynamics at low concentrations and in-cell, and then compute informative models from the measured EPR distances. Read more Student intake Open for Honours, Master, PhD, Summer scholar students Theme Physical and Biophysical Chemistry Read more Members Leader Prof. Thomas Huber Professor Researcher Mr Haocheng Qianzhu Postdoctoral Fellow Student Mr Andrew George PhD Candidate Edan Habel PhD Candidate Nathan Paul PhD Candidate News Incorporating an Unnatural Amino Acid To Improve NMR - JACS Spotlight Spotlights on Recent JACS Publications has highlighted a JACS paper recently published by Elwy Abdelkader, Haocheng Qianzhu, Yi Jiun Tan, Luke Adams, Thomas Huber and Gottfried Otting (10.1021/jacs.0c11971). Read the article toc
