The McLeod group employs a wide range of techniques to study drug metabolism.

About

The McLeod group employs a wide range of techniques to study drug metabolism. These include chemical and enzymatic synthesis of drugs and their metabolites, methods of in vitro metabolism coupled with analysis by GC-MS-MS or LC-MS-MS, and molecular biology to engineer improved enzymes with anti-doping applications.

The group is also active in the area of medicinal chemistry of nicotinic acetylcholine receptors (nAChRs). Here our goal is the development of new drugs to treat neurological disorders and the application of tools like covalent trapping, an extension of the substituted cysteine accessibility method, to better understand where drugs bind on nAChRs.

Publications

Projects

Our goal is to develop an anti-malarial Trojan horse that will deliver a chemical payload to the malaria parasite that it cannot avoid, thus limiting the potential for resistance.

Theme

Medicinal Chemistry and Drug Development, Organic chemistry

Student intake

Open for Bachelor, Honours, Master students

Status

Potential

This project will develop powerful methods of liquid chromatography-mass spectrometry, coding and computational data analysis to study sulfate metabolites in mammalian systems with the goal of generating freely available tools that reveal the true complexity and roles of sulfate metabolites

Theme

Analytical Chemistry and Sensors

Student intake

Open for Bachelor, Honours, Master students

Status

Potential

This project develops faster, cost-effective drug checking methods using spectroscopy, spectrometry, and machine learning to identify harmful substances and monitor emerging drug trends, supporting public health and safety.

Theme

Analytical Chemistry and Sensors, Organic chemistry

Student intake

Open for Bachelor, Honours, Master students

Status

Current

Members

Leader

Prof. Malcolm McLeod

Associate Professor

Researcher

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Postdoctoral Fellow

Student

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PhD Candidate

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PhD Candidate

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PhD Candidate

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Postdoctoral Fellow

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PhD Candidate

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PhD Candidate

News

Congratulations to Associate Professor Malcolm McLeod - 2020 Churchill Fellowship Award Recipient.

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