Our goal is to develop an anti-malarial Trojan horse that will deliver a chemical payload to the malaria parasite that it cannot avoid, thus limiting the potential for resistance.

This project uses robotics and high-throughput platforms to accelerate chemoselective reaction development in small molecules and peptides, focusing on photochemical and electrochemical methods to create bioactive libraries for drug discovery.

This project will involve collaboration with industry partners (Beta Therapeutics) and partners within the Centre of Excellence in Peptide and Protein Science.

This project is centered on developing an artificial living biomineralisation platform for self-reinforcing materials.

This project will capitalise on these achievements and explore biocompatible synthetic routes to various kinds of bicycles and their applications in drug discovery.

This project will screen numerous boronic acid derivatives available at the Research School of Chemistry (optional: computational screening of data banks). Screening hits will be modified to generate drug-like inhibitors with anti-dengue activity.

This project targets broad-spectrum antiviral drug development by designing and testing molecules that inhibit viral proteases—key enzymes in RNA virus replication—using covalent “warheads” like alpha-ketoamides to identify new therapeutic leads.

This project will explore additional opportunities for the efficient electrochemical modification of peptides, including through the use of novel “electrochemically-active” amino acids.

This project will involve collaboration with the ANU Our Health in Our Hands Grand Challenge teams in the College of Engineering & Computer Science and the Research School of Physics.

This project is centered on developing a new methodology that would allow the prediction of the behaviours of genetically engineered microbes in engineered living materials (ELMs).

This project will explore phage display (Nobel prize 2018) as the most robust approach and establish this technique at the Research School of Chemistry.

This project will involve collaboration with partners within the Centre of Excellence in Peptide and Protein Science.

This project is expected to protect important agriculture crops with a novel class of chemical fungicides, contributing to global food security and delivering substantial environmental benefits

The Malins group is interested in several anti-cancer, antimalarial, and antibiotic peptides. 2023-2024 projects in this space will involve the chemical synthesis, structural modification, and biological evaluation of peptide leads as next-generation therapies.

The successful candidate will get to rationally design 3D printed solid-state vasculature for organ-on-a-chip models.